Origin of Species
For this piece Darwin's "On the Origin of Species" was translated into genetic sequence via a computer algorithm using Craig Venter's "watermark" for Celera's first artificially constructed chromosome (Gibson et. al, Science, 2011).
The ultimate result of this translation would be the construction of a DNA molecule, which could then be manipulated or allowed to "evolve" by adding the necessary replication machinery and reaction conditions. The book itself would be preserved (albeit with mutations) in the form of the DNA molecule.
The book displayed here is the translation, which ended up being 1,464 pages long.